VRT-043198

• Target :

  Others|||Drug Metabolite|||Caspase

• Related Pathways :

  Others|||Proteases/Proteasome|||Apoptosis|||Metabolism

• Bioactivity :

  VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective, and blood-brain barrier permeable inhibitor of the interleukin-converting enzyme/caspase-1 subfamily caspases, displaying Ki values of 0.8 nM for ICE/caspase-1 and 0.6 nM for caspase-4, respectively.

• Smiles :

  CC(C)(C)[C@H](NC(=O)c1ccc(N)c(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C=O

• Molecular Formula :

  C22H29ClN4O6

• Molecular Weight :

  480.94

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  244133-31-1