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VRT-043198

CAT: 0931-T69632Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T69632Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
244133-31-1
Target
Others, Drug Metabolite, Caspase
Related Pathways
Others, Proteases/Proteasome, Apoptosis, Metabolism
Bioactivity
VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective, and blood-brain barrier permeable inhibitor of the interleukin-converting enzyme/caspase-1 subfamily caspases, displaying Ki values of 0.8 nM for ICE/caspase-1 and 0.6 nM for caspase-4, respectively.
Smiles
CC(C)(C)[C@H](NC(=O)c1ccc(N)c(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C=O
Molecular Formula
C22H29ClN4O6
Molecular Weight
480.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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