GNE-0439

• Target:

  Sodium Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Purity:

  0.996

• Bioactivity:

  GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.

• Smiles:

  C(N[C@@H]([C@@H](C)C)C(O)=O)(=O)C1=CC=C(C=C1)C2CCC(CCC)CC2

• Molecular Formula:

  C21H31NO3

• Molecular Weight:

  345.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1241902-40-8