AMG-628, (S) -

• Target:

  Others|||TRP/TRPV Channel

• Related Pathways:

  Others|||Membrane transporter/Ion channel

• Bioactivity:

  AMG-628, (S) -, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.

• Smiles:

  O(C1=C2C(SC(NC(C)=O)=N2)=CC=C1)C=3C=C(N=CN3)N4CCN([C@@H](C)C5=CC=C(F)C=C5)CC4

• Molecular Formula:

  C25H25FN6O2S

• Molecular Weight:

  492.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  862269-92-9