(S) -AMG-628

CAT: 0804-HY-169780Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169780Size:1 Each
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Description
(S) -AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374) . (S) -AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448) - and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S) -AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA- (HY-153808) induced inflammatory pain models[1].
CAS Number
[862269-92-9]
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
CC(NC1=NC(C(S1)=CC=C2)=C2OC3=NC=NC(N4CCN(CC4)[C@H](C5=CC=C(C=C5)F)C)=C3)=O
Molecular Formula
C25H25FN6O2S
Molecular Weight
492.57
References & Citations
[1]Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50 (15) :3528-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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