(S) -AMG-628

• Description:

  (S) -AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374) . (S) -AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448) - and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S) -AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA- (HY-153808) induced inflammatory pain models[1].

• UNSPSC:

  12352005

• Target:

  TRP Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  CC(NC1=NC(C(S1)=CC=C2)=C2OC3=NC=NC(N4CCN(CC4)[C@H](C5=CC=C(C=C5)F)C)=C3)=O

• Molecular Formula:

  C25H25FN6O2S

• Molecular Weight:

  492.57

• References & Citations:

  [1]Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50 (15) :3528-39.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [862269-92-9]