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KW-2450 free base

CAT: 0931-T68405-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T68405-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
904899-25-8
Target
Apoptosis, Aurora Kinase, IGF-1R
Related Pathways
Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Apoptosis, Cell Cycle/Checkpoint
Purity
0.9911
Bioactivity
KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
Smiles
C(=C/C1=C(NC(=O)C=2SC=CC2C)C=C(CN3CCN(C(CO)=O)CC3)C=C1)\C=4C=5C(NN4)=CC=CC5
Molecular Formula
C28H29N5O3S
Molecular Weight
515.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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