Paritaprevir free base

• Target:

  SARS-CoV|||HCV Protease

• Related Pathways:

  Microbiology/Virology|||Proteases/Proteasome

• Purity:

  0.9957

• Bioactivity:

  Paritaprevir free base (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity against HCV genotype 1. Upon administration, paritaprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, and infection is associated with the development of hepatocellular carcinoma (HCC) .

• Smiles:

  Cc1cnc (cn1) C (=O) N[C@H]1CCCCC\C=C/[C@@H]2C[C@]2 (NC (=O) [C@@H]2C[C@H] (CN2C1=O) Oc1nc2ccccc2c2ccccc12) C (=O) NS (=O) (=O) C1CC1

• Molecular Formula:

  C40H43N7O7S

• Molecular Weight:

  765.89

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1221573-85-8