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GPX4-IN-18

CAT: 0931-T212550-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212550-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Glutathione Peroxidase, ROS, Cannabinoid Receptor, Ferroptosis
Related Pathways
Metabolism, Immunology/Inflammation, Apoptosis, GPCR/G Protein
Bioactivity
GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4), and it also acts as a ferroptosis inducer. It enhances the production of reactive oxygen species (ROS) and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal carcinoma cells. In HT-1080 cells, GPX4-IN-18 induces ferroptosis with IC50 values of 0.007 μM (without iron inhibitor-1) and 1.486 μM (with iron inhibitor-1) . Additionally, GPX4-IN-18 reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 xenograft mouse model.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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