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Hedgehog IN-11

CAT: 0931-T212033-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212033-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Hedgehog/Smoothened, DNA Methyltransferase, Apoptosis
Related Pathways
GPCR/G Protein, Stem Cells, Apoptosis, Chromatin/Epigenetic
Bioactivity
HedgehogIN-11 is an orally active Hedgehog inhibitor. It reduces resistance to Temozolomide (TMZ) by downregulating O6-methylguanine-deoxyribonucleotides methyltransferase (MGMT) expression through the Hedgehog pathway. HedgehogIN-11 significantly inhibits the migration and invasion of TMZ-resistant glioblastoma cells and induces apoptosis. Computational modeling predicts good blood-brain barrier penetration for HedgehogIN-11. This compound is applicable for glioblastoma (GBM) research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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