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Hedgehog Antagonist VIII

CAT: 0931-T35537-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T35537-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
330796-24-2
Target
Others, Hedgehog/Smoothened
Related Pathways
Stem Cells, Others, GPCR/G Protein
Bioactivity
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.
Smiles
FC1=CC=C(C=C1)N1C(=O)C2=C(C=CC=C2)N=C1CNC(=O)NC1=CC=C(Cl)C(=C1)C(F)(F)F
Molecular Formula
C23H15ClF4N4O2
Molecular Weight
490.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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