Hedgehog IN-6

Hedgehog IN-6

• CAS Number: 2916444-33-0
• UNSPSC Description: Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization[1].
• Target Antigen: Hedgehog; Smo
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hedgehog-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(CCC(NCCCC)=O)[C@]2([H])CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]2([H])CC1
• Molecular Weight: 389.61
• References & Citations: [1]Liu YB, et al. A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened. Cell Chem Biol. 2024 Feb 28:S2451-9456(24)00076-X.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported