Products for Research Use Only
RegisterLogin

Hedgehog IN-11

CAT: 0804-HY-175299Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-175299Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Hedgehog IN-11 is an orally active Hedgehog inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM).
UNSPSC
12352005
Target
Apoptosis; DNA Methyltransferase; Hedgehog
Related Pathways
Apoptosis; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(OC1=CC2=C(C3=C(C4=C2C=C(C(OC)=C4)OC)CN5CCC[C@]5(C3)[H])C=C1)C(N=N6)=CN6CC7=CC=C(C(F)(F)F)C=C7
Molecular Formula
C33H29F3N4O4
Molecular Weight
602.60
References & Citations
[1]Feng Z, et al. Discovery of 1,2,3-triazole derivatives of phenanthroindolizidine to reverse temozolomide resistance in glioblastoma. Bioorg Chem. 2025 Aug;163:108752.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGMT

Related Products

CatalogName
HY-162372Hedgehog IN-6
HY-176056Hedgehog IN-9
HY-122814-01Hedgehog IN-1
HY-14115Hedgehog IN-10
HY-153456Hedgehog IN-2
HY-153730Hedgehog IN-5
HY-153457Hedgehog IN-3
HY-159511Hedgehog IN-7
HY-W838042-01Hedgehog IN-8
HY-111040-01Hedgehog agonist 1

Alternative Products

CatalogName
GTR19264348-01Hedgehog IN-11
479307DHH (Desert Hedgehog Protein, Desert Hedgehog)
491674SHH (Sonic Hedgehog Protein, Sonic Hedgehog)
483417IHH (Indian Hedgehog Protein, Indian Hedgehog)
T200011-01Hedgehog IN-7
T75148-01Hedgehog IN-3
MO15112Desert Hedgehog
MO15043Sonic Hedgehog
M14103-01Hedgehog-IN-7d
T207432-01Hedgehog IN-9

Popular Products