RIPK2-IN-8

CAT: 0931-T211556-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T211556-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3036254-29-9
Target
Interleukin|||NF-?B|||p38 MAPK|||RIP kinase
Related Pathways
Apoptosis|||MAPK|||NF-?B|||Immunology/Inflammation
Bioactivity
RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor with an IC50 of 11 nM. It exhibits greater selectivity for RIPK2 over RIPK1 (IC50 > 30,000 nM) and has moderate inhibitory effects on RIPK3 (IC50 = 44.61 nM) . RIPK2-IN-8 exerts anti-inflammatory effects by inhibiting the NOD2-RIPK2 signaling pathway and the expression of inflammatory cytokines IL-6 and TNF?. Additionally, in models of acute liver injury (ALI), RIPK2-IN-8 demonstrates both anti-inflammatory and hepatoprotective effects, making it useful for ALI research.
Smiles
O=C(NC1CC=C(C=2SC3=C(N=CN=C3NC4=CC=5N=CSC5C=C4F)C2)CC1)CC
Molecular Formula
C22H20FN5OS2
Molecular Weight
453.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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