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LO-3-61

CAT: 0931-T211321-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211321-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
E1/E2/E3 Enzyme, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, Ubiquitination
Bioactivity
LO-3-61 is a JQ-1 analog featuring a truncated fumarylamide group, classified as a BRD4 degrader with PROTAC (protein degradation targeting chimera) properties. It promotes the degradation of both long and short BRD4 isoforms via a CUL4DCAF16-dependent pathway. In MDA-MB-231 cells, LO-3-61 exhibits selectivity in degrading BRD3 and BRD4.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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