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LO-4-25

CAT: 0931-T206941-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206941-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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