MD-4251

CAT: 0931-T210814-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210814-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PROTACs, Casein Kinase, MDM-2/p53, IKZF

Related Pathways

PROTAC, Metabolism, Stem Cells, Apoptosis, Immunology/Inflammation

Bioactivity

MD-4251 is an orally active MDM2 PROTAC degrader. It potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and activates p53. MD-4251 exhibits strong antiproliferative activity against acute leukemia cells with wild-type p53, but shows limited efficacy in mutant cells. In RS4;11 xenograft mouse models, MD-4251 induces complete tumor regression.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MD-4251

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