MD-4251

CAT: 0931-T210814-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T210814-01Size:10 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs|||Casein Kinase|||MDM-2/p53|||IKZF
Related Pathways
PROTAC|||Metabolism|||Stem Cells|||Apoptosis|||Immunology/Inflammation
Bioactivity
MD-4251 is an orally active MDM2 PROTAC degrader. It potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and activates p53. MD-4251 exhibits strong antiproliferative activity against acute leukemia cells with wild-type p53, but shows limited efficacy in mutant cells. In RS4;11 xenograft mouse models, MD-4251 induces complete tumor regression.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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