MD-4251

• Target:

  PROTACs|||Casein Kinase|||MDM-2/p53|||IKZF

• Related Pathways:

  PROTAC|||Metabolism|||Stem Cells|||Apoptosis|||Immunology/Inflammation

• Bioactivity:

  MD-4251 is an orally active MDM2 PROTAC degrader. It potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and activates p53. MD-4251 exhibits strong antiproliferative activity against acute leukemia cells with wild-type p53, but shows limited efficacy in mutant cells. In RS4;11 xenograft mouse models, MD-4251 induces complete tumor regression.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C