MD-222

• Target:

  MDM-2/p53|||PROTACs|||E1/E2/E3 Enzyme

• Related Pathways:

  Apoptosis|||PROTAC|||Ubiquitination

• Bioactivity:

  MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].

• Smiles:

  Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)Nc1ccc(cc1)C(=O)NCCCCCc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

• Molecular Formula:

  C48H47Cl2FN6O6

• Molecular Weight:

  893.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2136246-72-3