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MD-4251

CAT: 0013-GTR19263322-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263322-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MD-4251 is an orally active MDM2 PROTAC degrader. It potently degrades MDM2 in RS4;11 cells (DC50: 0.2 nM) and activates p53. MD-4251 exhibits strong antiproliferative activity against acute leukemia cells with wild-type p53, but shows limited efficacy in mutant cells. In RS4;11 xenograft mouse models, MD-4251 induces complete tumor regression.
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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