MD-265

• Target :

  PROTACs|||MDM-2/p53

• Related Pathways :

  PROTAC|||Apoptosis

• Bioactivity :

  MD-265 is a PROTAC degrader that targets and degrades MDM2, leading to the activation of p53 in cancer cells with wild-type p53. MD-265 achieves complete tumor regression and enhances long-term survival in leukemic mice.

• Smiles :

  O=C1[C@@]2(C3(N[C@@H](C(N[C@@H]4CC[C@@H](C(=O)N5CCC(C#CC6=C7C(C(=O)N(C7)C8C(=O)NC(=O)CC8)=CC=C6)CC5)CC4)=O)[C@@H]2C9=C(F)C(Cl)=CC=C9)CCCCC3)C=%10C(N1)=CC(Cl)=CC%10

• Molecular Formula :

  C50H51Cl2FN6O6

• Molecular Weight :

  921.88

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2415160-21-1