MD-265

CAT: 0931-MF-0112215-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0112215-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2415160-21-1
Target
PROTACs|||MDM-2/p53
Related Pathways
PROTAC|||Apoptosis
Bioactivity
MD-265 is a PROTAC degrader that targets and degrades MDM2, leading to the activation of p53 in cancer cells with wild-type p53. MD-265 achieves complete tumor regression and enhances long-term survival in leukemic mice.
Smiles
O=C1[C@@]2(C3(N[C@@H](C(N[C@@H]4CC[C@@H](C(=O)N5CCC(C#CC6=C7C(C(=O)N(C7)C8C(=O)NC(=O)CC8)=CC=C6)CC5)CC4)=O)[C@@H]2C9=C(F)C(Cl)=CC=C9)CCCCC3)C=%10C(N1)=CC(Cl)=CC%10
Molecular Formula
C50H51Cl2FN6O6
Molecular Weight
921.88
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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