MD-224

• Target:

  Mdm2|||E1/E2/E3 Enzyme|||PROTACs|||MDM-2/p53

• Related Pathways:

  Ubiquitination|||PROTAC|||Apoptosis

• Purity:

  >99.99%

• Bioactivity:

  MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept, and as a new class of anticancer agent.

• Smiles:

  O=C1[C@@]2([C@]3(N[C@@H](C(NC4=CC=C(C(NCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C=C4)=O)[C@@H]2C8=C(F)C(Cl)=CC=C8)CCCCC3)C=9C(N1)=CC(Cl)=CC9

• Molecular Formula:

  C48H43Cl2FN6O6

• Molecular Weight:

  889.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2136247-12-4