A2AR modulator-1

• Target:

  Adenosine Receptor

• Related Pathways:

  Neuroscience|||GPCR/G Protein

• Bioactivity:

  A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.

• Smiles:

  N#CC1=C (N=C (C (C#N) =C1C=2C=CC=C (C2) C3=CN=CC=C3) N4CCCCC4) N

• Molecular Formula:

  C23H20N6

• Molecular Weight:

  380.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3007566-23-3