SJF 1528

CAT: 0931-MF-0052335Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0052335Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2230821-38-0
Target
Others|||PROTACs|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||PROTAC|||Angiogenesis|||JAK/STAT signaling|||Others
Bioactivity
Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells) . Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells) .
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(cc2)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)C(C)(C)C)cc1|@:67|
Molecular Formula
C55H57ClFN7O8S
Molecular Weight
1030.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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