SJF 1528

• CAS Number :

  2230821-38-0

• Target :

  Others|||PROTACs|||EGFR

• Related Pathways :

  Tyrosine Kinase/Adaptors|||PROTAC|||Angiogenesis|||JAK/STAT signaling|||Others

• Bioactivity :

  Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells) . Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells) .

• Smiles :

  Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(cc2)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)C(C)(C)C)cc1|@:67|

• Molecular Formula :

  C55H57ClFN7O8S

• Molecular Weight :

  1030.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C