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(Rac) -BDA-366

CAT: 0931-T208727-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T208727-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
142645-19-0
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
(Rac) -BDA-366 (example 2) is the racemate of BDA-366, a potent Bcl-2 antagonist with a Ki of 3.3 nM. It shows high affinity and selectivity for the Bcl-2-BH4 domain. BDA-366 induces a conformational change in Bcl-2, neutralizing its anti-apoptotic function and converting Bcl-2 from a survival molecule into a cell death inducer. Additionally, BDA-366 can inhibit the growth of lung cancer cells.
Smiles
O=C1C=2C=CC=CC2C(=O)C=3C(=CC=C(NCC(O)CN(CC)CC)C13)NCC4OC4
Molecular Formula
C24H29N3O4
Molecular Weight
423.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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