(Rac) -BDA-366

• Target:

  Bcl-2 Family

• Related Pathways:

  Apoptosis

• Bioactivity:

  (Rac) -BDA-366 (example 2) is the racemate of BDA-366, a potent Bcl-2 antagonist with a Ki of 3.3 nM. It shows high affinity and selectivity for the Bcl-2-BH4 domain. BDA-366 induces a conformational change in Bcl-2, neutralizing its anti-apoptotic function and converting Bcl-2 from a survival molecule into a cell death inducer. Additionally, BDA-366 can inhibit the growth of lung cancer cells.

• Smiles:

  O=C1C=2C=CC=CC2C(=O)C=3C(=CC=C(NCC(O)CN(CC)CC)C13)NCC4OC4

• Molecular Formula:

  C24H29N3O4

• Molecular Weight:

  423.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  142645-19-0