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A-366

CAT: 0931-T3624-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T3624-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1527503-11-2
Target
Epigenetic Reader Domain, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.998
Bioactivity
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families.
Smiles
COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1
Molecular Formula
C19H27N3O2
Molecular Weight
329.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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