A-366

• Target:

  Epigenetic Reader Domain|||Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Purity:

  0.998

• Bioactivity:

  A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families.

• Smiles:

  COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1

• Molecular Formula:

  C19H27N3O2

• Molecular Weight:

  329.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1527503-11-2