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(rac) -Talazoparib

CAT: 0931-T204239-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204239-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1207454-56-5
Target
PARP
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
(rac) -Talazoparib ((rac) -BMN-673) (Compound 47) is an orally active inhibitor of PARP1/2, with Ki values of 1.2 nM and 0.87 nM, respectively. It inhibits cellular PARylation at an EC50 of 2.51 nM. This compound leads to the accumulation of DNA damage and suppresses the proliferation of BRCA1/2-mutated MX-1 and Capan-1 cells, with IC50 values of 0.3 nM and 5 nM, respectively. Additionally, (rac) -Talazoparib exhibits antitumor activity in mouse models.
Smiles
O=C1NN=C2C=3C(=CC(F)=CC13)NC(C4=CC=C(F)C=C4)C2C5=NC=NN5C
Molecular Formula
C19H14F2N6O
Molecular Weight
380.351
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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