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(Rac) -BDA-366

CAT: 0804-HY-101083ASize: 1 EachDry Ice: NoHazardous: No
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Description
(Rac) -BDA-366 (example 2) is the despinner of BDA-366. BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1][2].
CAS Number
142645-19-0
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-bda-366.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NCC3OC3)C=CC(NCC(O)CN(CC)CC)=C2C(C4=CC=CC=C41)=O
Molecular Formula
C24H29N3O4
Molecular Weight
423.50
References & Citations
[1]Spinx Pharmaceuticals Corp. Preparation of bis (hydroxyalkylamino) anthraquinones as protein kinase C inhibitors. World Intellectual Property Organization, WO9207557 A1 1992-05-14|[2]Han B, Park D, Li R, et al. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015;27 (6) :852-863.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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