EGFR-IN-91

CAT: 0931-T208228-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T208228-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3032113-20-2

Target

EGFR

Related Pathways

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

Bioactivity

EGFR-IN-91 (compound 9) is an orally active EGFR inhibitor capable of crossing the blood-brain barrier. It effectively inhibits EGFRL858R/C797S and EGFRexon 19del/C797S, leading to tumor regression in patient-derived xenograft (PDX) mouse models. EGFR-IN-91 shows potential for inhibiting locally advanced and metastatic non-small cell lung cancer (NSCLC) driven by EGFR mutations.

Smiles

FC=1C(Cl)=CC=CC1NC=2N=CN=C3C=C(OC)C(OCCON4CCN(C)CC4)=CC32

Molecular Formula

C22H25ClFN5O3

Molecular Weight

461.92

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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