YX-02-030

CAT: 0013-GTR19261252-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19261252-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.

CAS Number

3049076-98-1

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Smiles

C[C@@]1 (N (C (=O) N2CCN (CC (NCCOCCOCCOCC (N[C@H] (C (=O) N3[C@H] (C (NCC4=CC=C (C=C4) C5=C (C) N=CS5) =O) C[C@@H] (O) C3) [C@@] (C) (C) C) =O) =O) CC2) C (=N[C@@]1 (C) C6=CC=C (Cl) C=C6) C7=C (OCC) C=C (C (C) (C) C) C=C7) C8=CC=C (Cl) C=C8

Molecular Formula

C66H85Cl2N9O10S

Molecular Weight

1267.41

Storage Conditions

-20°C

Notes

For research use only.

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