PRMT5-IN-50

• Target :

  Histone Methyltransferase

• Related Pathways :

  Chromatin/Epigenetic

• Bioactivity :

  PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.

• Smiles :

  C(N(CC1=CC=C(C(F)(F)F)C=N1)[C@H](C)C=2N=CC=CN2)(=O)C3=CC4=C(N=C(N)C(=C4)C5CC5)C=C3

• Molecular Formula :

  C26H23F3N6O

• Molecular Weight :

  492.496

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3002409-47-1