PRMT5-IN-19

• Target:

  Histone Methyltransferase|||Others

• Related Pathways:

  Others|||Chromatin/Epigenetic

• Bioactivity:

  PRMT5-IN-19 (Compound 41) is a potent, orally active PRMT5 inhibitor, exhibiting selectivity towards the SAM-binding pocket of PRMT5 with IC50 values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay) . It effectively blocks methyltransferase activity and demonstrates high specificity against other PRMTs and PKMTs, exerting anti-proliferative effects through apoptosis induction and holding potential in cancer-related research [1].

• Molecular Formula:

  C25H24N4O

• Molecular Weight:

  396.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C