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P53/TLR2 modulator-1

CAT: 0931-T206433-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206433-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
MDM-2/p53, MyD88, Apoptosis, Bcl-2 Family, Interleukin, TLR
Related Pathways
Apoptosis, Immunology/Inflammation
Bioactivity
P53/TLR2 modulator-1 (Compound Z9) is an agent that targets both the P53 pathway and TLR2, exhibiting radioprotective properties. It mitigates apoptosis by inhibiting radiation-induced expression of P53 and Bax. Concurrently, it enhances the TLR2 pathway by upregulating downstream proteins MyD88 and P65, which promotes secretion of cytokines like IL-6, providing radioprotective effects. P53/TLR2 modulator-1 shows significant radioprotective activity in AHH-1 and HUVECs cells, enhances survival rates in C57BL/6J mice exposed to lethal radiation doses, and alleviates radiation-induced damage to their hematopoietic system, intestinal villi, and spleen. It is applicable for research on radiation-related diseases.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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