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FLT3-ITD-IN-3

CAT: 0931-T206057-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206057-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3018150-80-3
Target
Apoptosis, FLT
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML) .
Smiles
O=C1C=C(C(=NN1C2=CC(Cl)=CC=C2F)C(=O)NC3=CC=C(OC=4C=CN=C(C4)NC(=O)N5CC(O)C5)C(F)=C3)C
Molecular Formula
C27H21ClF2N6O5
Molecular Weight
582.943
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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