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KRAS inhibitor-27

CAT: 0931-T205081-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205081-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3033690-83-1
Target
Ras, ERK, p38 MAPK
Related Pathways
MAPK, GPCR/G Protein
Bioactivity
KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.
Smiles
N#CC1=C(SC2=C(F)C=CC(C=3C(F)=C4N=C(N=C5C4=C(OCC6N5CCCOC6)C3Cl)OCC78N(CCC7)CC(F)C8)=C12)N
Molecular Formula
C31H28ClF3N6O3S
Molecular Weight
657.106
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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