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KRAS inhibitor-37

CAT: 0931-T201259-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T201259-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3058573-95-5
Target
Ras
Related Pathways
GPCR/G Protein, MAPK
Bioactivity
KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM) . This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.
Smiles
FC=1C=2C3=C(N4[C@](COC3=NC1C=5C(=C(Cl)C=C6C5C=NN6)C7CC7)(COCCC4)[H])N=C(OC[C@@]89N(CC(=C)C8)CCC9)N2
Molecular Formula
C32H33ClFN7O3
Molecular Weight
618.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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