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SPA0355

CAT: 0931-T204711-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204711-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1251839-15-2
Target
NF-κB, Akt, p38 MAPK, RANKL/RANK
Related Pathways
MAPK, NF-κB, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand) -induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.
Smiles
S=C(NC1=CC=C(OCCN2C=3C=CC=CC3OC=4C=CC=CC42)C=C1)NC
Molecular Formula
C22H21N3O2S
Molecular Weight
391.486
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BAC83915SPA0355

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