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SPA0355

CAT: 0804-HY-169703Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169703Size:1 Each
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Description
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis[1].
CAS Number
1251839-15-2
UNSPSC
12352005
Target
Akt; NF-κB; p38 MAPK; RANKL/RANK
Related Pathways
MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Smiles
S=C(NC)NC1=CC=C(C=C1)OCCN2C3=C(OC4=C2C=CC=C4)C=CC=C3
Molecular Formula
C22H21N3O2S
Molecular Weight
391.49
References & Citations
[1]Sang Hoon Kim, et al. SPA0355 prevents ovariectomy-induced bone loss in mice. Korean J Physiol Pharmacol. 2018 Dec 26;23 (1) :47–54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-Methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
CAS Number1251839-15-2
PubChem CID56593432
IUPAC Name1-methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
Molecular FormulaC22H21N3O2S
Molecular Weight391.5
XLogP4.5
Topological Polar Surface Area77.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity490
SMILES
CNC(=S)NC1=CC=C(C=C1)OCCN2C3=CC=CC=C3OC4=CC=CC=C42
InChI
InChI=1S/C22H21N3O2S/c1-23-22(28)24-16-10-12-17(13-11-16)26-15-14-25-18-6-2-4-8-20(18)27-21-9-5-3-7-19(21)25/h2-13H,14-15H2,1H3,(H2,23,24,28)
InChIKey
IEFRKIYTMPORCY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
CAS: 1251839-15-2
CID: 56593432
Formula: C22H21N3O2S
MW: 391.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass391.13544809
Monoisotopic Mass391.13544809
Topological Polar Surface Area77.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity490
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BAC83915SPA0355

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