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SPA0355

CAT: 0013-GTR19249950-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249950-02Size:10 mg
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Description
SPA0355 is a thiourea-based small molecule that inhibits osteoclast formation and promotes osteoblast differentiation. It suppresses RANKL-induced MAPK, Akt, and NF-κB pathways in vitro and protects against bone loss in ovariectomized mouse models, making it a valuable research tool for studying bone metabolism and osteoporosis.
CAS Number
1251839-15-2
Field of Research
Signal Transduction
Smiles
S=C (NC1=CC=C (OCCN2C=3C=CC=CC3OC=4C=CC=CC42) C=C1) NC
Molecular Formula
C22H21N3O2S
Molecular Weight
391.486
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-Methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
CAS Number1251839-15-2
PubChem CID56593432
IUPAC Name1-methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
Molecular FormulaC22H21N3O2S
Molecular Weight391.5
XLogP4.5
Topological Polar Surface Area77.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity490
SMILES
CNC(=S)NC1=CC=C(C=C1)OCCN2C3=CC=CC=C3OC4=CC=CC=C42
InChI
InChI=1S/C22H21N3O2S/c1-23-22(28)24-16-10-12-17(13-11-16)26-15-14-25-18-6-2-4-8-20(18)27-21-9-5-3-7-19(21)25/h2-13H,14-15H2,1H3,(H2,23,24,28)
InChIKey
IEFRKIYTMPORCY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
CAS: 1251839-15-2
CID: 56593432
Formula: C22H21N3O2S
MW: 391.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass391.13544809
Monoisotopic Mass391.13544809
Topological Polar Surface Area77.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity490
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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