Products for Research Use Only
RegisterLogin

SPA0355

CAT: 0931-T204711-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T204711-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1251839-15-2
Target
NF-κB, Akt, p38 MAPK, RANKL/RANK
Related Pathways
MAPK, NF-κB, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand) -induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.
Smiles
S=C(NC1=CC=C(OCCN2C=3C=CC=CC3OC=4C=CC=CC42)C=C1)NC
Molecular Formula
C22H21N3O2S
Molecular Weight
391.486
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

1-Methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
CAS Number1251839-15-2
PubChem CID56593432
IUPAC Name1-methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
Molecular FormulaC22H21N3O2S
Molecular Weight391.5
XLogP4.5
Topological Polar Surface Area77.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity490
SMILES
CNC(=S)NC1=CC=C(C=C1)OCCN2C3=CC=CC=C3OC4=CC=CC=C42
InChI
InChI=1S/C22H21N3O2S/c1-23-22(28)24-16-10-12-17(13-11-16)26-15-14-25-18-6-2-4-8-20(18)27-21-9-5-3-7-19(21)25/h2-13H,14-15H2,1H3,(H2,23,24,28)
InChIKey
IEFRKIYTMPORCY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
CAS: 1251839-15-2
CID: 56593432
Formula: C22H21N3O2S
MW: 391.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass391.13544809
Monoisotopic Mass391.13544809
Topological Polar Surface Area77.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity490
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BAC83915SPA0355

Popular Products