TRK-IN-30

CAT: 0931-T204692-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204692-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, ERK, PI3K, Trk receptor

Related Pathways

Tyrosine Kinase/Adaptors, Apoptosis, MAPK, PI3K/Akt/mTOR signaling

Bioactivity

TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.

Smiles

COC1=C(C=C(C=C1)NC(=O)C2=C(C(=CC=C2)NC3=CC4=C(C=C3)C(=CN4)C#N)N)OC

Molecular Formula

C24H21N5O3

Molecular Weight

427.455

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19249970-01	TRK-IN-30
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338192-01	Trk A
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