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KRAS inhibitor-40

CAT: 0931-T204518-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204518-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3059496-56-6
Target
Ras, PERK, Kras
Related Pathways
GPCR/G Protein, Apoptosis, MAPK
Bioactivity
KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.
Smiles
O=C1OCC(C)(C)CC=2C=3C=C(C=C4C3N(C2C5=CC(=CN=C5C(OC)C)N6CCOCC6)CC(F)(F)C4)C=7N=C(SC7)CC(NC(=O)C(N(C(=O)C8(F)CCN(C(=O)C(F)Cl)CC8)C)C(C)C)C(=O)N9NC1CCC9
Molecular Formula
C53H66ClF4N9O8S
Molecular Weight
1100.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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MBS5814771KRAS G12C Inhibitor 40
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