LSD1-IN-34

CAT: 0931-T89432-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T89432-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Monoamine Oxidase, Histone Demethylase, TGF-beta/Smad

Related Pathways

Stem Cells, Neuroscience, Chromatin/Epigenetic

Bioactivity

LSD1-IN-34 (Compound 7d) is an orally effective inhibitor of lysine-specific demethylase (LSD) and monoamine oxidase (MAO), exhibiting IC50 values of 4.51 nM for LSD1 and 18.46 nM for MAO A. This compound inhibits activation of neonatal rat cardiac fibroblasts (NRCF) induced by angiotensin II (Ang II) and shows no significant toxicity at 20 μM. LSD1-IN-34 also inhibits the TGFβ/Smad signaling pathway, contributing to the improvement of heart failure in mice. Moreover, it demonstrates favorable pharmacokinetic properties in rats.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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LSD1-IN-34

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