JBJ-07-149

• CAS Number :

  2140807-58-3

• Target :

  EGFR

• Related Pathways :

  Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

• Bioactivity :

  JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 ?M when used alone, and 0.148 ?M when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].

• Smiles :

  O=C1C2=CC(=CC=C2CN1C(C(=O)NC3=NC=CS3)C=4C=CC=CC4)C=5C=NC(=CC5)N6CCNCC6

• Molecular Formula :

  C28H26N6O2S

• Molecular Weight :

  510.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C