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JBJ-09-063 TFA

CAT: 0931-T74561-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74561-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
EGFR, Others
Related Pathways
Tyrosine Kinase/Adaptors, Others, Angiogenesis, JAK/STAT signaling
Bioactivity
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50 values of 0.147 nM for EGFR L858R, 0.063 nM for EGFR L858R/T790M, 0.083 nM for EGFR L858R/T790M/C797S, and 0.396 nM for EGFR L747S mutations. It effectively reduces phosphorylation of EGFR, Akt, and ERK1/2, demonstrating efficacy in models both sensitive and resistant to EGFR tyrosine kinase inhibitors (TKI) . JBJ-09-063 TFA holds potential for research in EGFR-mutant lung cancer [1].
Molecular Formula
C33H30F4N4O5S
Molecular Weight
670.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
MBS5806604JBJ-09-063
HY-147183A-01JBJ-09-063 (TFA)
MBS5814691JBJ-09-063 hydrochloride
MBS5816507JBJ-09-063 TFA
HY-147183B-01JBJ-09-063 (hydrochloride)
A24162-10JBJ-09-063 hydrochloride 10mg
A24162-50JBJ-09-063 hydrochloride 50mg
A24162-100JBJ-09-063 hydrochloride 100mg
A24162-5JBJ-09-063 hydrochloride 5mg
MBS3600959-01TAK-063

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