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PDE1-IN-4

CAT: 0931-T63776-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63776-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, PDE, Calcium Channel
Related Pathways
Metabolism, Others, Membrane transporter/Ion channel
Bioactivity
PDE1-IN-4 is a potent and selective inhibitor of PDE1 (phosphodiesterase-1), acting on PDE1C (IC50: 10 nM), PDE1A (IC50: 145 nM) and PDE1B (IC50: 354 nM) . PDE1-IN-4 regulates cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate) and exhibits antifibrotic effects. PDE1-IN-4 can inhibit TGF-β1-induced differentiation of human lung fibroblasts, and can be used to study idiopathic pulmonary fibrosis (IPF) .
Molecular Formula
C33H33N3O4
Molecular Weight
535.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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