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MGD-4

CAT: 0931-T201701-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T201701-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2991817-99-1
Target
IKZF|||E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC|||Immunology/Inflammation
Bioactivity
MGD-4 is an orally active, Cereblon (CRBN) -dependent degrader of IKAROS proteins that demonstrates dose-dependent degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) . The compound effectively inhibits the growth of multiple myeloma.
Smiles
O=C1C=2C=CC=C(N)C2CN(N1C3C(=O)NC(=O)CC3)C
Molecular Formula
C14H16N4O3
Molecular Weight
288.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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