MGD-4

• Target :

  IKZF|||E3 Ligase Ligand-Linker Conjugate

• Related Pathways :

  PROTAC|||Immunology/Inflammation

• Bioactivity :

  MGD-4 is an orally active, Cereblon (CRBN) -dependent degrader of IKAROS proteins that demonstrates dose-dependent degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) . The compound effectively inhibits the growth of multiple myeloma.

• Smiles :

  O=C1C=2C=CC=C(N)C2CN(N1C3C(=O)NC(=O)CC3)C

• Molecular Formula :

  C14H16N4O3

• Molecular Weight :

  288.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2991817-99-1