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MGD-22

CAT: 0931-T212276-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T212276-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2991818-12-1
Target
Molecular Glues|||IKZF|||Apoptosis
Related Pathways
Apoptosis|||Immunology/Inflammation|||PROTAC
Bioactivity
MGD-22 is a molecular glue and orally active degrader of IKZF1/2/3, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. It exhibits strong anti-proliferative activity against various hematological cancer cells and induces cell apoptosis (apoptosis) . MGD-22 demonstrates significant anti-tumor efficacy in mice with NCI-H929 or WSU-DLCL-2 xenografts. This compound is useful for researching blood cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL) .
Smiles
N#CC1=CC=C(C=C1)N2CCN(CC3=CC=C(C=C3)CNC4=CC=CC=5C(=O)N(N(C)CC45)C6C(=O)NC(=O)CC6)CC2
Molecular Formula
C33H35N7O3
Molecular Weight
577.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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