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PROTAC SMARCA2 degrader-26

CAT: 0931-T201143-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201143-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2760247-27-4
Target
Epigenetic Reader Domain, PROTACs
Related Pathways
PROTAC, Chromatin/Epigenetic
Bioactivity
PROTAC SMARCA2 degrader-26 (compound 45) is an effective degrader of SMARCA2 using the PROTAC technology. It induces degradation of SMARCA2 and SMARCA4 in VCaP cells, with degradation percentages of 94% and 57%, respectively. Additionally, PROTAC SMARCA2 degrader-26 demonstrates antiproliferative activity.
Smiles
C([C@@H](NC(CN1CCC(NC2=CC=C(C=C2)C=3C=C(N=NC3)C4=C(O)C=CC=C4)CC1)=O)[C@@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5
Molecular Formula
C46H54N8O5S
Molecular Weight
831.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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