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NLRP3-IN-51

CAT: 0931-T200772-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200772-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
NF-κB
Related Pathways
NF-κB
Bioactivity
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP) . This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU) . Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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