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NLRP3-IN-62

CAT: 0931-T203507-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203507-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3059965-71-5
Target
NOD-like Receptor (NLR), Pyroptosis
Related Pathways
Immunology/Inflammation, Apoptosis
Bioactivity
NLRP3-IN-62 (Compound 1) is an inhibitor of NLRP3. It effectively inhibits pyroptosis in THP-1 cells with an IC50 of 0.7 nM and suppresses IL-β release with an IC50 of 108.5 nM.
Smiles
O=C1C=C2C(=CN1)CN(C3=NC4=NC(=CC=C4O3)C5=C(O)C=C(C=C5C)C(F)(F)F)C2
Molecular Formula
C21H15F3N4O3
Molecular Weight
428.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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