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DPP-21

CAT: 0931-T200560-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T200560-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2924883-83-8
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
DPP-21 is an inhibitor of microtubule protein polymerization (IC50: 2.4 μM) . It exhibits antiproliferative activity against various cancer cell lines, with IC50 values of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23), and 9.37 nM (HepG2) . DPP-21 induces cell cycle arrest at the G2/M phase of mitosis and subsequently triggers apoptosis in tumor cells by decreasing Bcl-2 while increasing pro-apoptotic protein Bax levels.
Smiles
N1=C(N=C(C=2SC=CC12)N(C=3C=CC4=C(C=CN4C)C3)C)C
Molecular Formula
C17H16N4S
Molecular Weight
308.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N,2-dimethyl-N-(1-methylindol-5-yl)thieno[3,2-d]pyrimidin-4-amine
CAS Number2924883-83-8
PubChem CID171666129
IUPAC NameN,2-dimethyl-N-(1-methylindol-5-yl)thieno[3,2-d]pyrimidin-4-amine
Molecular FormulaC17H16N4S
Molecular Weight308.4
XLogP3.8
Topological Polar Surface Area62.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity406
SMILES
CC1=NC2=C(C(=N1)N(C)C3=CC4=C(C=C3)N(C=C4)C)SC=C2
InChI
InChI=1S/C17H16N4S/c1-11-18-14-7-9-22-16(14)17(19-11)21(3)13-4-5-15-12(10-13)6-8-20(15)2/h4-10H,1-3H3
InChIKey
WTDOSEGYWYJIAO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N,2-dimethyl-N-(1-methylindol-5-yl)thieno[3,2-d]pyrimidin-4-amine
CAS: 2924883-83-8
CID: 171666129
Formula: C17H16N4S
MW: 308.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.4
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass308.10956770
Monoisotopic Mass308.10956770
Topological Polar Surface Area62.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity406
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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