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HS-345

CAT: 0931-T200230-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T200230-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1462329-41-4
Target
Akt, Trk receptor
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors
Bioactivity
HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis) . Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.
Smiles
O=S(=O)(C=1C=C(C=NC1N)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)N(C)C
Molecular Formula
C19H18N6O2S
Molecular Weight
394.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-amino-N,N-dimethyl-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-sulfonamide
CAS Number1462329-41-4
PubChem CID71812242
IUPAC Name2-amino-N,N-dimethyl-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-sulfonamide
Molecular FormulaC19H18N6O2S
Molecular Weight394.5
XLogP1.8
Topological Polar Surface Area126
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity633
SMILES
CN(C)S(=O)(=O)C1=C(N=CC(=C1)C2=CC3=C(NC=C3C4=CC=NC=C4)N=C2)N
InChI
InChI=1S/C19H18N6O2S/c1-25(2)28(26,27)17-8-14(9-22-18(17)20)13-7-15-16(11-24-19(15)23-10-13)12-3-5-21-6-4-12/h3-11H,1-2H3,(H2,20,22)(H,23,24)
InChIKey
LKKJGBNHOXRBGF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-amino-N,N-dimethyl-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-sulfonamide
CAS: 1462329-41-4
CID: 71812242
Formula: C19H18N6O2S
MW: 394.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.5
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass394.12119501
Monoisotopic Mass394.12119501
Topological Polar Surface Area126 Ų
Heavy Atom Count28
Formal Charge0
Complexity633
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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